Blister Cell in G6PD Deficiency , Red Blood Cell with a clear vacuole like area on its membrane, resembling a blister., It usually results when splenic macrophages remove precipitated Heinz You Need More Riboflavin with G6PD Deficiency! G6PDHelp.com Role of G6PD in preventing RBC destruction Department of Genetic Engineering @ SRM University: Genetic Awareness Program on Glucose 6 Phosphate Dehydrogenase Deficiency G6PD Deficiency causes Haemolytic Anaemia Glucose 6 phosphate dehydrogenase is an enzyme in the hexose monophosphate shunt that synthesizes NADPH. The NADPH is used to convert oxidized glutathione (GSSG) to reduced glutathione (