Transcription factors are some of pharma's most elusive targets. But a new class of covalent peptides might finally crack them. Brian Paegel shares how his team is unlocking the "undruggable" and what DIHEXA Research Capsules Peptide Tech Solubility a of polyamides Polymer Solvents NMP DMAc DMF DMSO m cresol Download Table Dihexa (also known as PNB 0408) is an experimental small molecule derived from angiotensin IV. It was engineered to cross the bloodbrain barrier and has shown synaptogenic effects in preclinical models. The often quoted Dihexa is concentrated in multiple brain regions. Rats fitted with a Download Scientific Diagram