Full article: Nanozyme mediated glutathione depletion for enhanced ROS based cancer therapies: a comprehensive review The role of ROS in exercise mediated WAT browning. Exercise causes oxidative stress in skeletal muscle and reduces the level of GSH. GSH provides electrons for glutathione peroxidase (GPXs), which eliminates H2O2. Reducing Glutathione depletion induces oxidative injury and apoptosis via TRPM2 channel activation in renal collecting duct cells ScienceDirect Unearthing the secrets of mitochondrial ROS and glutathione in bioenergetics: Trends in Biochemical Sciences Heat induced longevity in budding yeast requires respiratory metabolism and glutathione recycling Figure f6 Aging