Melanotan What It Is and Its Relation to Skin Cancer Melanotic macule. Benign. Dark spot on labia (or lip). Analogous to lentigo simplex. Hyperpigmented basal keratinocytes & dermal melanophages. Slight in single basal melanocytes; NO nests. More info like this in What is Melanotan II the drug that the TGA urges consumers to avoid? Pigmented Lesions of the Oral Cavity Oral and Maxillofacial Surgery Clinics Labial Melanotic Macules in Atopic Dermatitis: An Observational Study Semantic Scholar